The beginning of what looks to be an interesting series of articles on hacking the human genome has been posted on O'Reilly's MacDev Center. Some interesting quotes:
On the UC Santa Cruz Genome Browser: "I'm not sure what Edward Tufte would have to say about the design of this, but there are a lot of annotations available and you need to see all of them to evaluate any given region."
There are a lot of well-characterized bacterial genomes available, and comparison of these gets really interesting.
I've been told that comparison of archaeal genomes is also "really interesting".
